Who is this for?
Researchers; no programming experience is needed.
How do you parallelize?
- PRS jobs distributed across nodes (batch)
- Sample and variant parallel
Tool category: Genetic Analysis Pipeline
Function: Polygenic Risk Scores
Tool type: Omics workflow
Key capabilities:
- Turnkey calculation of Polygenic Risk Scores (PRS).
- Novel method that combines shrinkage + ancestry-correction evolution of Cutler et al 2024
Potential use cases:
- Research studies to explain heritability of disease
- Prediction of risk in new populations: e.g., calculate risk in African population using European GWAS
- Identify cases enriched for rare variant disease burden